Decoy exosomes provide protection against bacterial toxins
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چکیده
منابع مشابه
Protection against Shiga Toxins
Shiga toxins consist of an A-moiety and five B-moieties able to bind the neutral glycosphingolipid globotriaosylceramide (Gb3) on the cell surface. To intoxicate cells efficiently, the toxin A-moiety has to be cleaved by furin and transported retrogradely to the Golgi apparatus and to the endoplasmic reticulum. The enzymatically active part of the A-moiety is then translocated to the cytosol, w...
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Bacterial toxins are virulence factors that manipulate host cell functions and take over the control of vital processes of living organisms to favor microbial infection. Some toxins directly target innate immune cells, thereby annihilating a major branch of the host immune response. In this review we will focus on bacterial toxins that act from the extracellular milieu and hinder the function o...
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Certain bacteria, such as enterohemorrhagic Escherichia coli O157:H7, are difficult to treat because destruction of the cells by standard antibiotics releases bacterial toxins. Pavel Kitov et al. have created a class of multivalent inhibitors that can bind and sequester such toxins through multiple, low-affinity interactions. The authors designed a polymer scaffold that aggregated the E. coli S...
متن کاملMultivalent bacterial inhibitor protects against toxins
Certain bacteria, such as enterohemorrhagic Escherichia coli O157:H7, are difficult to treat because destruction of the cells by standard antibiotics releases bacterial toxins. Pavel Kitov et al. have created a class of multivalent inhibitors that can bind and sequester such toxins through multiple, low-affinity interactions. The authors designed a polymer scaffold that aggregated the E. coli S...
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The parenteral (muscle) larvae of Trichinella spiralis were found much more susceptible than previously reported to the deleterious effect of ethanol in vitro. Larvae were reversibly paralyzed when immersed for 6 hours in water containing 6% ethanol; at concentrations of 12-25%, the paralysis was irreversible. When trichinous meat was digested in artificial gastric juice containing 6-12% ethano...
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ژورنال
عنوان ژورنال: Nature
سال: 2020
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-020-2066-6